WO1999067641A3 - Decoding of array sensors with microspheres - Google Patents

Decoding of array sensors with microspheres Download PDF

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Publication number
WO1999067641A3
WO1999067641A3 PCT/US1999/014387 US9914387W WO9967641A3 WO 1999067641 A3 WO1999067641 A3 WO 1999067641A3 US 9914387 W US9914387 W US 9914387W WO 9967641 A3 WO9967641 A3 WO 9967641A3
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WO
WIPO (PCT)
Prior art keywords
decoding
microspheres
array sensors
sensors
array
Prior art date
Application number
PCT/US1999/014387
Other languages
French (fr)
Other versions
WO1999067641A2 (en
Inventor
Mark S Chee
John R Stuelpnagel
Anthony W Czarnik
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26782312&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999067641(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Illumina Inc filed Critical Illumina Inc
Priority to JP2000556247A priority Critical patent/JP3662850B2/en
Priority to AU48315/99A priority patent/AU754952B2/en
Priority to DE69940430T priority patent/DE69940430D1/en
Priority to EP99931904.9A priority patent/EP1090293B2/en
Priority to CA2335951A priority patent/CA2335951C/en
Publication of WO1999067641A2 publication Critical patent/WO1999067641A2/en
Publication of WO1999067641A3 publication Critical patent/WO1999067641A3/en

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    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis

Abstract

The invention relates to compositions and methods for decoding microsphere array sensors.
PCT/US1999/014387 1998-06-24 1999-06-24 Decoding of array sensors with microspheres WO1999067641A2 (en)

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JP2000556247A JP3662850B2 (en) 1998-06-24 1999-06-24 Decoding array sensors with microspheres
AU48315/99A AU754952B2 (en) 1998-06-24 1999-06-24 Decoding of array sensors with microspheres
DE69940430T DE69940430D1 (en) 1998-06-24 1999-06-24 Decoding of matrix-like sensors by microparticles
EP99931904.9A EP1090293B2 (en) 1998-06-24 1999-06-24 Decoding of array sensors with microspheres
CA2335951A CA2335951C (en) 1998-06-24 1999-06-24 Decoding of array sensors with microspheres

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US9047398P 1998-06-24 1998-06-24
US18954398A 1998-11-10 1998-11-10
US60/090,473 1998-11-10
US09/189,543 1998-11-10

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7754498B2 (en) 1997-10-06 2010-07-13 Trustees Of Tufts College Self-encoding sensor with microspheres
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US8691754B2 (en) 2003-09-22 2014-04-08 Bioarray Solutions, Ltd. Microparticles with enhanced covalent binding capacity and their uses
US8691594B2 (en) 1996-04-25 2014-04-08 Bioarray Solutions, Ltd. Method of making a microbead array with attached biomolecules
US8883424B2 (en) 1999-05-21 2014-11-11 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8906626B2 (en) 2000-02-07 2014-12-09 Illumina, Inc. Multiplex nucleic acid reactions
US9147037B2 (en) 2004-08-02 2015-09-29 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US9251583B2 (en) 2002-11-15 2016-02-02 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US9273354B2 (en) 1997-05-23 2016-03-01 Illumina, Inc. System and apparatus for sequential processing of analytes
US9279148B2 (en) 1999-04-20 2016-03-08 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US9377388B2 (en) 1997-03-14 2016-06-28 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US9399795B2 (en) 1998-06-24 2016-07-26 Illumina, Inc. Multiplex decoding of array sensors with microspheres
US9416411B2 (en) 1999-08-18 2016-08-16 Illumina, Inc. Compositions and methods for preparing oligonucleotide solutions
US9436088B2 (en) 2001-06-21 2016-09-06 Bioarray Solutions, Ltd. Un-supported polymeric film with embedded microbeads

Families Citing this family (383)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US8236500B2 (en) 1997-10-23 2012-08-07 The United States Of America, As Represented By The Department Of Veterans Affairs Promoter variants of the alpha-7 nicotinic acetylcholine receptor
US6642062B2 (en) * 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
US7510841B2 (en) * 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
JP4454155B2 (en) 1999-01-08 2010-04-21 アプライド バイオシステムズ， エルエルシー Fiber arrays for contacting chemical species and methods of using and making fiber arrays
US7595189B2 (en) 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
ATE462970T1 (en) 1999-02-09 2010-04-15 Illumina Inc SCREENING METHOD USING POROUS MICROBEADS AND COMPOSITIONS
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
EP1923472B1 (en) 1999-04-20 2012-04-11 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
EP1190100B1 (en) 1999-05-20 2012-07-25 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
AU2246601A (en) 1999-08-30 2001-04-10 Illumina, Inc. Methods for improving signal detection from an array
WO2001057494A2 (en) * 2000-01-20 2001-08-09 The Regents Of The University Of California Chemical sensor system utilizing microjet technology
CA2398107C (en) * 2000-01-28 2013-11-19 Althea Technologies, Inc. Methods for analysis of gene expression
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
AU2001239760B2 (en) * 2000-02-10 2005-11-24 Illumina, Inc. Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
EP1257668B1 (en) 2000-02-16 2008-10-29 Illumina, Inc. Parallel genotyping of multiple patient samples
US6759235B2 (en) * 2000-04-06 2004-07-06 Quantum Dot Corporation Two-dimensional spectral imaging system
US6921637B2 (en) * 2000-05-04 2005-07-26 The Cbr Institute For Biomedical Research, Inc. Colloid compositions for solid phase biomolecular analytical, preparative and identification systems
US7682837B2 (en) 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
EP1349954B1 (en) * 2000-05-19 2011-01-26 Eragen Biosciences, Inc. Materials and methods for detection of nucleic acids
US9709559B2 (en) * 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
ES2259666T3 (en) * 2000-06-21 2006-10-16 Bioarray Solutions Ltd MOLECULAR ANALYSIS OF MULTIPLE ANALYTICS USING SERIES OF RANDOM PARTICLES WITH APPLICATION SPECIFICITY.
AU7166201A (en) * 2000-06-28 2002-01-08 Illumina Inc Composite arrays utilizing microspheres with a hybridization chamber
ATE399216T1 (en) 2000-07-11 2008-07-15 Kirk Hogan METHODS AND COMPOSITIONS FOR PERIOPERATIVE GENOMIC PROFILING
US6676904B1 (en) * 2000-07-12 2004-01-13 Us Gov Sec Navy Nanoporous membrane immunosensor
AU1317502A (en) * 2000-10-14 2002-04-29 Eragen Biosciences Inc Solid support assay systems and methods utilizing non-standard bases
EP1395601A4 (en) * 2000-10-18 2006-04-12 Vitra Bioscience Inc Multiplexed cell analysis system
DE10054382A1 (en) * 2000-10-27 2002-05-08 Attomol Gmbh Molekulare Diagno Method and test kit for the detection of analytes in a sample
US7060442B2 (en) 2000-10-30 2006-06-13 Regents Of The University Of Michigan Modulators on Nod2 signaling
US6707548B2 (en) 2001-02-08 2004-03-16 Array Bioscience Corporation Systems and methods for filter based spectrographic analysis
US7572642B2 (en) 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US20030099949A1 (en) * 2001-10-05 2003-05-29 Surmodics, Inc. Arrays having clustered arrangements and methods of making and using
US7195913B2 (en) 2001-10-05 2007-03-27 Surmodics, Inc. Randomly ordered arrays and methods of making and using
EP2722395B1 (en) 2001-10-15 2018-12-19 Bioarray Solutions Ltd Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US7255986B2 (en) 2002-01-31 2007-08-14 The Board Of Trustees Operating Michigan State University Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets
US7499806B2 (en) * 2002-02-14 2009-03-03 Illumina, Inc. Image processing in microsphere arrays
US20030194705A1 (en) * 2002-03-01 2003-10-16 Schroth Gary P. Methods of using unnatural nucleobases for decoding
AU2003220254B2 (en) 2002-03-13 2008-09-18 Syngenta Participations, Ag. Nucleic acid detection method
WO2003102179A1 (en) * 2002-05-31 2003-12-11 Kankyo Engineering Co., Ltd. Novel method of assyaing nucleic acid using labeled nucleotide
US6730515B2 (en) * 2002-06-11 2004-05-04 Eastman Kodak Company Micro-array calibration means
CN100414296C (en) * 2002-06-14 2008-08-27 赵翀 Embedded high-pass three-dimensional biological detecting technique and agent box
US7462448B2 (en) 2002-08-02 2008-12-09 Stratatech Corporation Species specific DNA detection
US7157228B2 (en) * 2002-09-09 2007-01-02 Bioarray Solutions Ltd. Genetic analysis and authentication
US7595883B1 (en) * 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
ATE525469T1 (en) 2002-12-18 2011-10-15 Third Wave Tech Inc DETECTION OF SMALL NUCLEIC ACIDS
US7297780B2 (en) 2003-01-06 2007-11-20 Third Wave Technologies, Inc. Reactive functional groups for preparation of modified nucleic acid
EP1590482B1 (en) 2003-01-17 2008-12-10 Eragen Biosciences, Inc. Nucleic acid amplification using non-standard bases
AU2004227353B2 (en) 2003-04-01 2010-02-25 Luminex Corporation Polymerase inhibitor and method of using same
US7858301B2 (en) * 2003-05-07 2010-12-28 Bioarray Solutions, Ltd. Method of probe design for nucleic acid analysis by multiplexed hybridization
US7651850B2 (en) * 2003-05-16 2010-01-26 Board Of Regents, The University Of Texas System Image and part recognition technology
US20050026200A1 (en) * 2003-07-28 2005-02-03 Holden David P. Method for error detection and increased confidence of sample decoding
US7824856B2 (en) * 2003-09-10 2010-11-02 Althea Technologies, Inc. Expression profiling using microarrays
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
FR2860872A1 (en) * 2003-10-09 2005-04-15 Commissariat Energie Atomique MICRO-SENSORS AND NANO-SENSORS OF CHEMICAL AND BIOLOGICAL SPECIES WITH SURFACE PLASMONS
US20050089177A1 (en) * 2003-10-23 2005-04-28 International Business Machines Corporation Method, apparatus, and program for intelligent volume control
EP1692298A4 (en) 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimization of gene expression analysis using immobilized capture probes
ES2533876T3 (en) 2003-10-29 2015-04-15 Bioarray Solutions Ltd Multiplexed nucleic acid analysis by double stranded DNA fragmentation
WO2005047471A2 (en) * 2003-11-07 2005-05-26 U.S. Genomics, Inc. Improved fret efficiency methods
US7383261B2 (en) * 2004-01-16 2008-06-03 Xerox Corporation Reference database and method for determining spectra using measurements from an LED color sensor, and method of generating a reference database
WO2005081776A2 (en) * 2004-01-30 2005-09-09 Eragen Biosciences, Inc. Materials and methods for the detection of sars
US7432057B2 (en) 2004-01-30 2008-10-07 Michigan State University Genetic test for PSE-susceptible turkeys
US7462451B2 (en) 2004-04-26 2008-12-09 Third Wave Technologies, Inc. Compositions for modifying nucleic acids
US7622281B2 (en) * 2004-05-20 2009-11-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for clonal amplification of nucleic acid
US8536661B1 (en) 2004-06-25 2013-09-17 University Of Hawaii Biosensor chip sensor protection methods
US7440930B1 (en) * 2004-07-22 2008-10-21 Adobe Systems Incorporated Training an attentional cascade
US7697807B2 (en) * 2006-06-01 2010-04-13 Ut-Battelle, Llc Multi-tipped optical component
US7697808B2 (en) * 2004-07-27 2010-04-13 Ut-Battelle, Llc Multi-tipped optical component
US7406391B2 (en) * 2004-09-20 2008-07-29 Affymetrix, Inc. System, method, and computer product for detection instrument calibration
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
US7471385B2 (en) * 2005-01-13 2008-12-30 Xerox Corporation Systems and methods for selecting a reference database for determining a spectrum of an object based on fluorescence of the object
US7634142B1 (en) 2005-01-24 2009-12-15 Adobe Systems Incorporated Detecting objects in images using a soft cascade
WO2006101913A2 (en) * 2005-03-18 2006-09-28 Eragen Biosciences, Inc. Methods for detecting multiple species and subspecies of neiserria
EP1869230B1 (en) * 2005-03-23 2017-08-30 Bio-Rad Laboratories, Inc. Method for purifying proteins
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
US7507588B2 (en) * 2005-04-20 2009-03-24 Becton, Dickinson And Company Multiplex microparticle system
EP1883710A4 (en) * 2005-05-03 2009-07-08 Althea Technologies Inc Compositions and methods for the analysis of degraded nucleic acids
WO2006124664A2 (en) 2005-05-12 2006-11-23 Third Wave Technologies, Inc. Polymorphic ghsr nucleic acids and uses thereof
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
WO2006133184A2 (en) 2005-06-07 2006-12-14 Eragen Biosciences, Inc. Methods for detection and typing of nucleic acids
WO2007044711A1 (en) 2005-10-07 2007-04-19 University Of Florida Research Foundation, Inc. Multiple component nanoparticles for multiplexed signaling and optical encoding
US7727655B2 (en) * 2005-10-25 2010-06-01 Honeywell International Inc. Fuel cell stack having catalyst coated proton exchange member
CA2640385C (en) 2005-12-23 2014-07-15 Nanostring Technologies, Inc. Nanoreporters and methods of manufacturing and use thereof
DE102006029032A1 (en) * 2006-02-17 2007-08-23 Poly-An Gesellschaft zur Herstellung von Polymeren für spezielle Anwendungen und Analytik mbH Apparatus, method and kit for detecting analytes in a sample
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8933209B2 (en) 2006-04-26 2015-01-13 Abbvie Inc. Dep2 and its uses in major depressive disorder and other related disorders
US20100216657A1 (en) * 2006-05-16 2010-08-26 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
JP5081232B2 (en) * 2006-05-22 2012-11-28 ナノストリング テクノロジーズ， インコーポレイテッド System and method for analyzing nanoreporters
US7674924B2 (en) 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
EP2636755A1 (en) * 2006-05-26 2013-09-11 AltheaDx Incorporated Biochemical analysis of partitioned cells
JP5260503B2 (en) 2006-06-01 2013-08-14 サード ウェーブ テクノロジーズ，インコーポレーテッド Nucleic acid detection
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
EP4108780A1 (en) 2006-06-14 2022-12-28 Verinata Health, Inc. Rare cell analysis using sample splitting and dna tags
EP2024512A4 (en) 2006-06-14 2009-12-09 Artemis Health Inc Methods for the diagnosis of fetal abnormalities
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
WO2008016335A1 (en) * 2006-08-03 2008-02-07 National University Of Singapore A microarray system and a process for producing microarrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
US7501290B2 (en) * 2006-09-13 2009-03-10 Hanley Brian P Intraplexing method for improving precision of suspended microarray assays
GB0618514D0 (en) * 2006-09-20 2006-11-01 Univ Nottingham Trent Method of detecting interactions on a microarray using nuclear magnetic resonance
US7947487B2 (en) 2006-10-05 2011-05-24 Massachusetts Institute Of Technology Multifunctional encoded particles for high-throughput analysis
US7813013B2 (en) * 2006-11-21 2010-10-12 Illumina, Inc. Hexagonal site line scanning method and system
CA2672315A1 (en) 2006-12-14 2008-06-26 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale fet arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US20080241831A1 (en) * 2007-03-28 2008-10-02 Jian-Bing Fan Methods for detecting small RNA species
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
US7769548B2 (en) * 2007-05-10 2010-08-03 Illumina, Inc. Microarray analytical data stitching system and method
JP2010528608A (en) * 2007-06-01 2010-08-26 ４５４ ライフ サイエンシーズ コーポレイション System and method for identifying individual samples from complex mixtures
US9151751B2 (en) * 2007-06-29 2015-10-06 Applied Biosystems, Llc Systems and methods for electronic detection with nanoFETS
US20090029347A1 (en) * 2007-07-27 2009-01-29 Thornthwaite Jerry T Method for Identifying Multiple Analytes Using Flow Cytometry
ES2556627T3 (en) 2007-08-30 2016-01-19 Trustees Of Tufts College Methods to determine the concentration of an analyte in solution
US7767441B2 (en) * 2007-10-25 2010-08-03 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US7811810B2 (en) 2007-10-25 2010-10-12 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US20090181390A1 (en) * 2008-01-11 2009-07-16 Signosis, Inc. A California Corporation High throughput detection of micrornas and use for disease diagnosis
WO2009097368A2 (en) 2008-01-28 2009-08-06 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
US20090203086A1 (en) * 2008-02-06 2009-08-13 454 Life Sciences Corporation System and method for improved signal detection in nucleic acid sequencing
US20090253142A1 (en) 2008-03-15 2009-10-08 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules during amplification reactions
WO2009137521A2 (en) * 2008-05-07 2009-11-12 Illumina, Inc. Compositions and methods for providing substances to and from an array
US8470164B2 (en) 2008-06-25 2013-06-25 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
WO2010003132A1 (en) 2008-07-02 2010-01-07 Illumina Cambridge Ltd. Using populations of beads for the fabrication of arrays on surfaces
WO2010019826A1 (en) 2008-08-14 2010-02-18 Nanostring Technologies, Inc Stable nanoreporters
CN102159726A (en) * 2008-09-05 2011-08-17 生命科技公司 Methods and systems for nucleic acid sequencing validation, calibration and normalization
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8374818B2 (en) * 2008-12-19 2013-02-12 Affymetrix, Inc. System, method and apparatus for calibrating inspection tools
US8053744B2 (en) * 2009-04-13 2011-11-08 Src, Inc. Location analysis using nucleic acid-labeled tags
US8343775B2 (en) * 2009-05-06 2013-01-01 Hanley Brian P Method and device for affinity differential intraplexing
US9767342B2 (en) 2009-05-22 2017-09-19 Affymetrix, Inc. Methods and devices for reading microarrays
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
CN102665753A (en) 2009-07-31 2012-09-12 佛多斯大学医学研究中心 Methods for diagnosing or predicting hepatitis c outcome in hcv infected patients
US9785683B2 (en) 2009-09-25 2017-10-10 Adnan Fakeih Database and method for evaluating data therefrom
US9317537B2 (en) * 2009-09-25 2016-04-19 Adnan Fakeih Database and method for evaluating data therefrom
WO2011047087A2 (en) 2009-10-13 2011-04-21 Nanostring Technologies, Inc. Protein detection via nanoreporters
US8440406B2 (en) * 2009-10-23 2013-05-14 Luminex Corporation Amplification primers with non-standard bases for increased reaction specificity
CA2779750C (en) 2009-11-06 2019-03-19 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive diagnosis of graft rejection in organ transplant patients
US9448180B2 (en) 2009-12-15 2016-09-20 Flir Detection, Inc. Multi-analyte detection system and method
GB0922377D0 (en) 2009-12-22 2010-02-03 Arab Gulf University The Mutant LDL receptor
US8965076B2 (en) 2010-01-13 2015-02-24 Illumina, Inc. Data processing system and methods
JP5914362B2 (en) 2010-02-11 2016-05-11 ナノストリング テクノロジーズ， インコーポレイテッド Compositions and methods for the detection of small RNA molecules
US9169515B2 (en) * 2010-02-19 2015-10-27 Life Technologies Corporation Methods and systems for nucleic acid sequencing validation, calibration and normalization
US8236574B2 (en) * 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
ES2544635T3 (en) 2010-03-01 2015-09-02 Quanterix Corporation Methods to extend the dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
JP5893607B2 (en) 2010-04-05 2016-03-23 プログノシス バイオサイエンシズ インコーポレイテッドＰｒｏｇｎｏｓｙｓ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． Spatial-encoded biological assay
CA2802049C (en) * 2010-06-07 2018-07-10 Firefly Bioworks, Inc. Scanning multifunctional particles
US8703493B2 (en) 2010-06-15 2014-04-22 Src, Inc. Location analysis using fire retardant-protected nucleic acid-labeled tags
JP5952813B2 (en) 2010-06-30 2016-07-13 ライフ テクノロジーズ コーポレーション Method and apparatus for testing ISFET arrays
AU2011226767B1 (en) 2010-06-30 2011-11-10 Life Technologies Corporation Ion-sensing charge-accumulation circuits and methods
US8731847B2 (en) 2010-06-30 2014-05-20 Life Technologies Corporation Array configuration and readout scheme
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
EP2589065B1 (en) 2010-07-03 2015-08-19 Life Technologies Corporation Chemically sensitive sensor with lightly doped drains
US8716027B2 (en) 2010-08-03 2014-05-06 Src, Inc. Nucleic acid-labeled tags associated with odorant
WO2012036679A1 (en) 2010-09-15 2012-03-22 Life Technologies Corporation Methods and apparatus for measuring analytes
US8483969B2 (en) 2010-09-17 2013-07-09 Illuminia, Inc. Variation analysis for multiple templates on a solid support
EP2619564B1 (en) 2010-09-24 2016-03-16 Life Technologies Corporation Matched pair transistor circuits
US9039996B2 (en) 2010-10-12 2015-05-26 Stmicroelectronics, Inc. Silicon substrate optimization for microarray technology
WO2012083072A2 (en) 2010-12-16 2012-06-21 Agilent Technologies, Inc. LIGATION METHOD EMPLOYING EUKARYOTIC tRNA LIGASE
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
WO2012135340A2 (en) 2011-03-28 2012-10-04 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
EP3907299A1 (en) 2011-04-15 2021-11-10 The Johns Hopkins University Safe sequencing system
EP2699903B1 (en) 2011-04-20 2018-07-18 Life Technologies Corporation Methods, compositions and systems for sample deposition
US8478545B2 (en) 2011-06-03 2013-07-02 Agilent Technologies, Inc. Identification of aberrant microarray features
US20140154209A1 (en) 2011-06-30 2014-06-05 Centre Hospitalier Universitaire Vaudois Polymorphisms associated with non-response to a hepatitis c treatment or susceptibility to non-spontaneous hepatitis c clearance
JP5822929B2 (en) * 2011-07-19 2015-11-25 株式会社日立ハイテクノロジーズ Nucleic acid analyzer
WO2013030786A1 (en) 2011-08-31 2013-03-07 Centre Hospitalier Universitaire Vaudois Method for diagnosing or predicting hepatocellular carcinoma outcome
US9435812B2 (en) 2011-08-31 2016-09-06 Ventana Medical Systems, Inc. Expression of ETS related gene (ERG) and phosphatase and tensin homolog (PTEN) correlates with prostate cancer capsular penetration
WO2013043922A1 (en) 2011-09-22 2013-03-28 ImmuMetrix, LLC Compositions and methods for analyzing heterogeneous samples
DK3623481T3 (en) 2011-09-23 2021-11-15 Illumina Inc COMPOSITIONS FOR NUCLEIC ACID SEQUENCE
US20140271542A1 (en) 2011-10-05 2014-09-18 The United States Of America As Represented By The Secretary, Department Of Health And Human Service Genetic marker for predicting prognosis in patients infected with hepatitis c virus
US10501791B2 (en) 2011-10-14 2019-12-10 President And Fellows Of Harvard College Sequencing by structure assembly
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
EP2788499B1 (en) 2011-12-09 2016-01-13 Illumina, Inc. Expanded radix for polymeric tags
US11021737B2 (en) 2011-12-22 2021-06-01 President And Fellows Of Harvard College Compositions and methods for analyte detection
US10227639B2 (en) 2011-12-22 2019-03-12 President And Fellows Of Harvard College Compositions and methods for analyte detection
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US8838394B2 (en) * 2012-02-03 2014-09-16 California Institute Of Technology Signal encoding and decoding in multiplexed biochemical assays
EP2836482B1 (en) 2012-04-10 2019-12-25 The Regents of The University of California Compositions and methods for treating cancer
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
CA2881685C (en) 2012-08-14 2023-12-05 10X Genomics, Inc. Microcapsule compositions and methods
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP2912468B1 (en) 2012-10-29 2018-09-12 The Johns Hopkins University Papanicolaou test for ovarian and endometrial cancers
GB201219487D0 (en) 2012-10-30 2012-12-12 Cancer Rec Tech Ltd Anti-S100A4 antibody molecules and their uses
US10829816B2 (en) 2012-11-19 2020-11-10 Apton Biosystems, Inc. Methods of analyte detection
RU2670133C2 (en) 2012-11-19 2018-10-18 Аптон Биосистемс, Инк. Digital analysis of molecular analytes using single molecule detection
GB201220924D0 (en) 2012-11-21 2013-01-02 Cancer Res Inst Royal Materials and methods for determining susceptibility or predisposition to cancer
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
EP2954065B1 (en) 2013-02-08 2021-07-28 10X Genomics, Inc. Partitioning and processing of analytes and other species
US10138509B2 (en) 2013-03-12 2018-11-27 President And Fellows Of Harvard College Method for generating a three-dimensional nucleic acid containing matrix
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
DK3327123T3 (en) 2013-03-15 2019-11-25 Lineage Biosciences Inc METHODS FOR SEQUENCING THE IMMUN REPERTOIR
CN105051525B (en) 2013-03-15 2019-07-26 生命科技公司 Chemical device with thin conducting element
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
CN105283758B (en) 2013-03-15 2018-06-05 生命科技公司 Chemical sensor with consistent sensor surface area
CN105264366B (en) 2013-03-15 2019-04-16 生命科技公司 Chemical sensor with consistent sensor surface area
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
US9618520B2 (en) 2013-04-25 2017-04-11 Vladislav B. Bergo Microarray compositions and methods of their use
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
CN104769110A (en) * 2013-05-22 2015-07-08 奥林巴斯株式会社 Nucleic acid analysis kit and nucleic acid analysis method
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
WO2014210225A1 (en) 2013-06-25 2014-12-31 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
JP6585046B2 (en) 2013-08-22 2019-10-02 アプトン バイオシステムズ インコーポレイテッド Method for digital analysis of molecular analytes using electrical methods
JO3805B1 (en) 2013-10-10 2021-01-31 Araxes Pharma Llc Inhibitors of kras g12c
CN106132555B (en) 2013-11-11 2019-07-26 生命科技股份有限公司 Rotor stack and its application method
US9828284B2 (en) 2014-03-28 2017-11-28 Ut-Battelle, Llc Thermal history-based etching
CN106795553B (en) 2014-06-26 2021-06-04 10X基因组学有限公司 Methods of analyzing nucleic acids from individual cells or cell populations
US10179932B2 (en) 2014-07-11 2019-01-15 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
EP3175023A4 (en) 2014-07-30 2018-03-07 President and Fellows of Harvard College Systems and methods for determining nucleic acids
JO3556B1 (en) 2014-09-18 2020-07-05 Araxes Pharma Llc Combination therapies for treatment of cancer
WO2016049524A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2016049568A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Methods and compositions for inhibition of ras
EP3234575B1 (en) 2014-12-18 2023-01-25 Life Technologies Corporation Apparatus for measuring analytes using large scale fet arrays
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
KR102593647B1 (en) 2014-12-18 2023-10-26 라이프 테크놀로지스 코포레이션 High data rate integrated circuit with transmitter configuration
US10363288B2 (en) 2015-01-14 2019-07-30 National Jewish Health Insulin mimotopes and methods of using the same
CA2976946C (en) 2015-02-24 2023-09-19 City Of Hope Chemically encoded spatially addressed library screening platforms
US10774374B2 (en) 2015-04-10 2020-09-15 Spatial Transcriptomics AB and Illumina, Inc. Spatially distinguished, multiplex nucleic acid analysis of biological specimens
BR112017021869A2 (en) 2015-04-10 2018-12-11 Araxes Pharma Llc substituted quinazoline compounds and methods of use thereof
MX2017013275A (en) 2015-04-15 2018-01-26 Araxes Pharma Llc Fused-tricyclic inhibitors of kras and methods of use thereof.
DK3294911T3 (en) 2015-05-11 2020-11-16 Illumina Inc Platform for discovery and analysis of therapeutic agents
US9612224B2 (en) 2015-05-29 2017-04-04 International Business Machines Corporation High density nano-array for sensing
US10501777B2 (en) 2015-07-17 2019-12-10 Nanostring Technologies, Inc. Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
EP3325650B1 (en) 2015-07-17 2024-01-03 Nanostring Technologies, Inc. Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
US10689356B2 (en) 2015-09-28 2020-06-23 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
EP3356349A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
WO2017058728A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10647703B2 (en) 2015-09-28 2020-05-12 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058792A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
EP3356354A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
WO2017058807A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
CN108351352B (en) * 2015-10-05 2021-09-10 北卡罗来纳-查佩尔山大学 Decoding method for multiplex assays and related fluidic devices, kits and solid supports
JP2018533939A (en) 2015-10-19 2018-11-22 アラクセス ファーマ エルエルシー Method for screening for inhibitors of RAS
MX2018005611A (en) 2015-11-03 2018-11-09 Harvard College Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix.
KR20180081596A (en) 2015-11-16 2018-07-16 아락세스 파마 엘엘씨 Substituted quinazoline compounds comprising substituted heterocyclic groups and methods for their use
US9988357B2 (en) 2015-12-09 2018-06-05 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
EP3432877B1 (en) 2016-03-24 2023-01-11 ImmunoMolecular Therapeutics, Inc. D-alpha-methyldopa for treating autoimmune disease
US10822312B2 (en) 2016-03-30 2020-11-03 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
CN109415761B (en) 2016-04-25 2022-09-20 哈佛学院董事及会员团体 Hybrid chain reaction method for in situ molecular detection
US10066263B2 (en) 2016-06-17 2018-09-04 California Institute Of Technology Nucleic acid reactions and related methods and compositions
WO2018009547A1 (en) 2016-07-05 2018-01-11 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Diagnosing col6-related disorders and methods for treating same
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
WO2018035134A1 (en) 2016-08-15 2018-02-22 Omniome, Inc. Method and system for sequencing nucleic acids
CN109923216A (en) 2016-08-31 2019-06-21 哈佛学院董事及会员团体 By the detection combination of biomolecule to the method for the single test using fluorescent in situ sequencing
CN109983125A (en) 2016-08-31 2019-07-05 哈佛学院董事及会员团体 The method for generating the nucleic acid sequence library for detecting by fluorescent in situ sequencing
US10280172B2 (en) 2016-09-29 2019-05-07 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
CN110312711A (en) 2016-10-07 2019-10-08 亚瑞克西斯制药公司 Heterocyclic compound and its application method as RAS inhibitor
GB201619458D0 (en) 2016-11-17 2017-01-04 Spatial Transcriptomics Ab Method for spatial tagging and analysing nucleic acids in a biological specimen
CN116334202A (en) 2016-11-21 2023-06-27 纳米线科技公司 Chemical compositions and methods of use thereof
WO2018112420A1 (en) 2016-12-15 2018-06-21 The Regents Of The University Of California Compositions and methods for treating cancer
WO2018140599A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
EP3573967A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Fused hetero-hetero bicyclic compounds and methods of use thereof
EP3573971A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
EP3573954A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
WO2018140514A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
JP7305611B2 (en) 2017-03-17 2023-07-10 アプトン バイオシステムズ インコーポレイテッド Methods of sequencing and high-resolution imaging
WO2018178042A1 (en) * 2017-03-27 2018-10-04 Imicroq, S.L. Rapid pcr method for detection of pathogenic microorganisms
CN109789167A (en) 2017-04-14 2019-05-21 哈佛学院董事及会员团体 Method for generating cell-derived microfilament network
US9951385B1 (en) 2017-04-25 2018-04-24 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
WO2018218070A2 (en) 2017-05-25 2018-11-29 Araxes Pharma Llc Covalent inhibitors of kras
WO2018218069A1 (en) 2017-05-25 2018-11-29 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant kras, hras or nras
CN110869357A (en) 2017-05-25 2020-03-06 亚瑞克西斯制药公司 Compounds and methods of use thereof for treating cancer
WO2018218150A1 (en) 2017-05-26 2018-11-29 President And Fellows Of Harvard College Systems and methods for high-throughput image-based screening
AU2018342007A1 (en) 2017-08-07 2020-02-27 Board Of Regents, The University Of Texas Systems Methods and materials for assessing and treating cancer
KR20200051699A (en) 2017-09-07 2020-05-13 아뎁트릭스 코퍼레이션 Multiplexed bead array for proteomics
US11513057B2 (en) 2018-01-04 2022-11-29 Virginia Commonwealth University Systems and method for rapid identification and analysis of cells in forensic samples
SG11202007501SA (en) 2018-02-12 2020-09-29 Nanostring Technologies Inc Biomolecular probes and methods of detecting gene and protein expression
US11052060B2 (en) 2018-02-12 2021-07-06 The Regents Of The University Of Colorado, A Body Corporate Compounds and methods for treating autoimmunity
US11013707B2 (en) 2018-03-23 2021-05-25 The Regents Of The University Of Colorado, A Body Corporate Administration of oral methyldopa
US11549139B2 (en) 2018-05-14 2023-01-10 Nanostring Technologies, Inc. Chemical compositions and methods of using same
EP3836967A4 (en) 2018-07-30 2022-06-15 ReadCoor, LLC Methods and systems for sample processing or analysis
US20230323447A1 (en) 2018-08-28 2023-10-12 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic dna in a biological sample
EP3844308A1 (en) 2018-08-28 2021-07-07 10X Genomics, Inc. Resolving spatial arrays
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
SG11202102722SA (en) * 2018-10-25 2021-04-29 Illumina Inc Methods and compositions for identifying ligands on arrays using indexes and barcodes
WO2020123316A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Methods for determining a location of a biological analyte in a biological sample
GB201820341D0 (en) 2018-12-13 2019-01-30 10X Genomics Inc Method for transposase-mediated spatial tagging and analysing genomic DNA in a biological specimen
GB201820300D0 (en) 2018-12-13 2019-01-30 10X Genomics Inc Method for spatial tagging and analysing genomic DNA in a biological specimen
WO2020129462A1 (en) * 2018-12-21 2020-06-25 ソニー株式会社 Particle verification method, chip for capturing particles, and particle analysis system
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
CN114174531A (en) 2019-02-28 2022-03-11 10X基因组学有限公司 Profiling of biological analytes with spatially barcoded oligonucleotide arrays
CN113924041A (en) 2019-03-14 2022-01-11 因斯利克萨公司 Method and system for fluorescence detection based on time gating
WO2020190509A1 (en) 2019-03-15 2020-09-24 10X Genomics, Inc. Methods for using spatial arrays for single cell sequencing
WO2020198071A1 (en) 2019-03-22 2020-10-01 10X Genomics, Inc. Three-dimensional spatial analysis
EP3976820A1 (en) 2019-05-30 2022-04-06 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
CN117036248A (en) 2019-10-01 2023-11-10 10X基因组学有限公司 System and method for identifying morphological patterns in tissue samples
EP4055185A1 (en) 2019-11-08 2022-09-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
CN117078725A (en) 2019-11-21 2023-11-17 10X基因组学有限公司 Spatial analysis of analytes
FI3891300T3 (en) 2019-12-23 2023-05-10 10X Genomics Inc Methods for spatial analysis using rna-templated ligation
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US20210254140A1 (en) 2020-02-17 2021-08-19 10X Genomics, Inc. Situ analysis of chromatin interaction
JP2023514749A (en) 2020-02-21 2023-04-07 １０エックス ジェノミクス インコーポレイテッド Methods and compositions for integrated in situ spatial assays
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
EP4242325A3 (en) 2020-04-22 2023-10-04 10X Genomics, Inc. Methods for spatial analysis using targeted rna depletion
EP4153776A1 (en) 2020-05-22 2023-03-29 10X Genomics, Inc. Spatial analysis to detect sequence variants
EP4153775A1 (en) 2020-05-22 2023-03-29 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
EP4025692A2 (en) 2020-06-02 2022-07-13 10X Genomics, Inc. Nucleic acid library methods
AU2021283184A1 (en) 2020-06-02 2023-01-05 10X Genomics, Inc. Spatial transcriptomics for antigen-receptors
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
WO2021252591A1 (en) 2020-06-10 2021-12-16 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
AU2021294334A1 (en) 2020-06-25 2023-02-02 10X Genomics, Inc. Spatial analysis of DNA methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
US20220186300A1 (en) 2020-12-11 2022-06-16 10X Genomics, Inc. Methods and compositions for multimodal in situ analysis
WO2022140028A1 (en) 2020-12-21 2022-06-30 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
US20220228200A1 (en) 2021-01-19 2022-07-21 10X Genomics, Inc. Methods and compositions for internally controlled in situ assays
CN116724125A (en) 2021-01-26 2023-09-08 10X基因组学有限公司 Nucleic acid analogue probes for in situ analysis
WO2022174054A1 (en) 2021-02-13 2022-08-18 The General Hospital Corporation Methods and compositions for in situ macromolecule detection and uses thereof
WO2022187366A1 (en) 2021-03-03 2022-09-09 10X Genomics, Inc. Analyte detection in situ using nucleic acid origami
EP4301870A1 (en) 2021-03-18 2024-01-10 10X Genomics, Inc. Multiplex capture of gene and protein expression from a biological sample
WO2022256324A1 (en) 2021-06-01 2022-12-08 10X Genomics, Inc. Methods and compositions for analyte detection and probe resolution
CN117751197A (en) 2021-06-02 2024-03-22 10X基因组学有限公司 Sample analysis using asymmetric circularizable probes
CN113416766B (en) * 2021-07-02 2022-08-19 苏州拉索生物芯片科技有限公司 Decoding method of biochip
WO2023287888A1 (en) * 2021-07-13 2023-01-19 Basf Corporation Systems, methods, and computer-readable media for characterizing microspheric material
US20230026886A1 (en) 2021-07-13 2023-01-26 10X Genomics, Inc. Methods for preparing polymerized matrix with controllable thickness
WO2023015192A1 (en) 2021-08-03 2023-02-09 10X Genomics, Inc. Nucleic acid concatemers and methods for stabilizing and/or compacting the same
US20230061542A1 (en) 2021-08-16 2023-03-02 10X Genomics, Inc. Probes comprising a split barcode region and methods of use
KR20230028896A (en) * 2021-08-23 2023-03-03 경북대학교 산학협력단 Multiplex detection analysis apparatus of sample using deep learning-based decoding of encoding magnetic particles and method thereof
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
EP4305195A2 (en) 2021-12-01 2024-01-17 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
US20230242974A1 (en) 2021-12-27 2023-08-03 10X Genomics, Inc. Methods and compositions for rolling circle amplification
US20230279475A1 (en) 2022-01-21 2023-09-07 10X Genomics, Inc. Multiple readout signals for analyzing a sample
WO2023192616A1 (en) 2022-04-01 2023-10-05 10X Genomics, Inc. Compositions and methods for targeted masking of autofluorescence
US20230323427A1 (en) 2022-04-06 2023-10-12 10X Genomics, Inc. Methods and compositions for multiplex cell analysis
US20240035071A1 (en) 2022-06-17 2024-02-01 10X Genomics, Inc. Catalytic de-crosslinking of samples for in situ analysis
US20240101978A1 (en) 2022-08-12 2024-03-28 10X Genomics, Inc. Puma1 polymerases and uses thereof
WO2024040060A1 (en) 2022-08-16 2024-02-22 10X Genomics, Inc. Ap50 polymerases and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998040726A1 (en) * 1997-03-14 1998-09-17 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
WO1998050782A2 (en) * 1997-05-05 1998-11-12 Trustees Of Tufts College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
WO1999018434A1 (en) * 1997-10-06 1999-04-15 Trustees Of Tufts College Self-encoding fiber optic sensor

Family Cites Families (362)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3605829A (en) 1970-04-29 1971-09-20 Becton Dickinson Co Blood handling machine
BE793605A (en) 1972-01-03 1973-05-02 Rca Corp APPARATUS AND METHOD FOR CORRECTING A DEFECTIVE PHOTOGRAPHIC MASK
US4125314A (en) 1977-05-05 1978-11-14 Dr. Ralph M. Grant Engineering Consultants, Inc. Beam ratio control for holography
US4200110A (en) 1977-11-28 1980-04-29 United States Of America Fiber optic pH probe
US4224198A (en) 1978-05-26 1980-09-23 California Institute Of Technology Protein specific polymeric immunomicrospheres
JPS56122001U (en) 1980-02-20 1981-09-17
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4448485A (en) 1981-07-10 1984-05-15 Bell Telephone Laboratories, Incorporated Harmonic generation using a surface of metal particles
JPS58105065A (en) 1981-12-17 1983-06-22 Olympus Optical Co Ltd Analyzer based on emmunological agglutination
IL68507A (en) 1982-05-10 1986-01-31 Univ Bar Ilan System and methods for cell selection
US5272081A (en) 1982-05-10 1993-12-21 Bar-Ilan University System and methods for cell selection
US5310674A (en) 1982-05-10 1994-05-10 Bar-Ilan University Apertured cell carrier
US4499052A (en) 1982-08-30 1985-02-12 Becton, Dickinson And Company Apparatus for distinguishing multiple subpopulations of cells
US4593728A (en) 1982-11-20 1986-06-10 Whitehead Thomas P Dispensing device and recording apparatus
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4687732A (en) 1983-06-10 1987-08-18 Yale University Visualization polymers and their application to diagnostic medicine
US4582789A (en) 1984-03-21 1986-04-15 Cetus Corporation Process for labeling nucleic acids using psoralen derivatives
US4883750A (en) 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5879881A (en) 1985-04-04 1999-03-09 Hybritech, Incorporated Solid phase system for use in ligand-receptor assays
US4682895A (en) 1985-08-06 1987-07-28 Texas A&M University Fiber optic probe for quantification of colorimetric reactions
CA1292092C (en) 1985-08-21 1991-11-12 Biotope, Inc. Methods and devices for separating and detecting components in specific binding assays
US4772540A (en) 1985-08-30 1988-09-20 Bar Ilan University Manufacture of microsieves and the resulting microsieves
US4876187A (en) 1985-12-05 1989-10-24 Meiogenics, Inc. Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences
US5019350A (en) 1986-02-13 1991-05-28 Pfizer Hospital Products, Inc. Fluorescent polymers
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US4824789B1 (en) 1986-10-10 1996-08-13 Minnesota Mining & Mfg Gas sensor
US4798738A (en) 1986-10-10 1989-01-17 Cardiovascular Devices, Inc. Micro sensor
US4811218A (en) 1986-06-02 1989-03-07 Applied Biosystems, Inc. Real time scanning electrophoresis apparatus for DNA sequencing
US5254477A (en) 1986-06-25 1993-10-19 Trustees Of Tufts College Flourescence intramolecular energy transfer conjugate compositions and detection methods
US5252494A (en) 1986-06-25 1993-10-12 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix
US5114864A (en) 1986-06-25 1992-05-19 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using fluid erodible controlled release polymers for delivery of reagent formulations
US4822746A (en) 1986-06-25 1989-04-18 Trustees Of Tufts College Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors
US5143853A (en) 1986-06-25 1992-09-01 Trustees Of Tufts College Absorbance modulated fluorescence detection methods and sensors
JP2662215B2 (en) 1986-11-19 1997-10-08 株式会社日立製作所 Cell holding device
DE3681176D1 (en) 1986-12-01 1991-10-02 Molecular Biosystems Inc METHOD FOR INCREASING THE SENSITIVITY OF NUCLEIC ACID HYBRIDIZATION TESTS.
NO162946C (en) 1987-08-21 1990-03-14 Otto Soerensen DEVICE FOR MAGNETIC SEPARATION OF CELLS.
SE458968B (en) 1987-06-16 1989-05-22 Wallac Oy BIOSPECIFIC ANALYTICAL PROCEDURE FOR MULTIPLE ANALYTICS WHICH DO NOT INCLUDE PARTICULAR COATING AND LABELING WITH FLUORESCING LABEL SUBSTANCES
US5194300A (en) 1987-07-15 1993-03-16 Cheung Sau W Methods of making fluorescent microspheres
US5132242A (en) 1987-07-15 1992-07-21 Cheung Sau W Fluorescent microspheres and methods of using them
US4785814A (en) 1987-08-11 1988-11-22 Cordis Corporation Optical probe for measuring pH and oxygen in blood and employing a composite membrane
JP2559760B2 (en) 1987-08-31 1996-12-04 株式会社日立製作所 Cell delivery method
US4842783A (en) 1987-09-03 1989-06-27 Cordis Corporation Method of producing fiber optic chemical sensors incorporating photocrosslinked polymer gels
FR2621393B1 (en) 1987-10-05 1991-12-13 Toledano Jacques DEVICE FOR IMMUNOENZYMATIC DETECTION OF SUBSTANCES FROM A DROP OF BLOOD OR LIQUID FROM ANY BIOLOGICAL MEDIUM
JPH01283412A (en) 1988-02-17 1989-11-15 Ebara Infilco Co Ltd Switching device for water current in tank
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5002867A (en) 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
NO164622C (en) 1988-05-11 1990-10-24 Tore Lindmo BINAER IMMUNOMETRIC PARTICLE-BASED METHOD FOR MEASURING SPECIFIC SERUM ANTIGENS USING LIQUID FLOW MICROPHOTOMETRY AND A PREPARED TARGET SET UP THEREOF.
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5185243A (en) 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
US5026599A (en) 1988-08-29 1991-06-25 Minnesota Mining & Manufacturing Array of densely packed discrete metal microspheres coated on a substrate
US5185178A (en) 1988-08-29 1993-02-09 Minnesota Mining And Manufacturing Company Method of forming an array of densely packed discrete metal microspheres
US4852789A (en) * 1988-09-13 1989-08-01 Pond Sr Robert B Process for modifying the surface of metal or metal alloy substrates and surface modified products produced thereby
JPH02131202A (en) 1988-11-11 1990-05-21 Omron Tateisi Electron Co Manufacture of optical waveguide
US5575849A (en) 1988-11-25 1996-11-19 Canon Kabushiki Kaisha Apparatus for producing a substrate having a surface with a plurality of spherical dimples for photoconductive members
US5237016A (en) 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
JPH02299598A (en) * 1989-04-14 1990-12-11 Ro Inst For Molecular Genetics & Geneteic Res Determination by means of hybridization, together with oligonucleotide probe of all or part of extremely short sequence in sample of nucleic acid connecting with separate particle of microscopic size
US5061336A (en) 1989-05-01 1991-10-29 Soane Technologies, Inc. Gel casting method and apparatus
US5071531A (en) 1989-05-01 1991-12-10 Soane Technologies, Inc. Casting of gradient gels
US5110745A (en) 1989-06-01 1992-05-05 The Trustees Of The University Of Pennsylvania Methods of detecting glycated proteins
US5176881A (en) 1989-08-11 1993-01-05 The University Of Tennessee Research Corporation Fiber optic-based regenerable biosensor
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
KR910007824B1 (en) 1989-10-25 1991-10-02 한국과학기술원 Method for producing biosensor
US5015843A (en) 1990-02-15 1991-05-14 Polysense, Inc. Fiber optic chemical sensors based on polymer swelling
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5750015A (en) * 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5667976A (en) 1990-05-11 1997-09-16 Becton Dickinson And Company Solid supports for nucleic acid hybridization assays
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5637459A (en) 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
WO1991019813A1 (en) 1990-06-11 1991-12-26 The University Of Colorado Foundation, Inc. Nucleic acid ligands
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
EP0478319B1 (en) 1990-09-28 1997-04-02 Kabushiki Kaisha Toshiba Gene detection method
US5135627A (en) 1990-10-15 1992-08-04 Soane Technologies, Inc. Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography
CA2046713A1 (en) 1990-10-16 1992-04-17 Richard M. Martinelli Amplification of midivariant dna templates
WO1992008808A1 (en) 1990-11-14 1992-05-29 Siska Diagnostics, Inc. Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
EP0558671B1 (en) 1990-11-21 1999-01-27 Iterex Pharmaceuticals Ltd. Partnership Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures
US5105305A (en) 1991-01-10 1992-04-14 At&T Bell Laboratories Near-field scanning optical microscope using a fluorescent probe
US5244813A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
US5244636A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5320814A (en) 1991-01-25 1994-06-14 Trustees Of Tufts College Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample
US5250264A (en) 1991-01-25 1993-10-05 Trustees Of Tufts College Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
US5257182B1 (en) 1991-01-29 1996-05-07 Neuromedical Systems Inc Morphological classification system and method
US5380489A (en) 1992-02-18 1995-01-10 Eastman Kodak Company Element and method for nucleic acid amplification and detection using adhered probes
AU2348092A (en) 1991-07-16 1993-02-23 Transmed Biotech Incorporated Methods and compositions for simultaneous analysis of multiple analytes
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
JPH0580530A (en) 1991-09-24 1993-04-02 Hitachi Ltd Production of thin film pattern
WO1993008472A1 (en) * 1991-10-15 1993-04-29 Multilyte Limited Binding assay employing labelled reagent
JP3067347B2 (en) 1991-10-30 2000-07-17 株式会社島津製作所 Gel-like bead sorting equipment
US6051380A (en) * 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5326691A (en) * 1991-11-21 1994-07-05 John Hozier Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries
US5644048A (en) 1992-01-10 1997-07-01 Isis Pharmaceuticals, Inc. Process for preparing phosphorothioate oligonucleotides
US5301006A (en) 1992-01-28 1994-04-05 Advanced Micro Devices, Inc. Emission microscope
US5518863A (en) 1992-01-31 1996-05-21 Institut National D'optique Method of changing the optical invariant of multifiber fiber-optic elements
US5888723A (en) * 1992-02-18 1999-03-30 Johnson & Johnson Clinical Diagnostics, Inc. Method for nucleic acid amplification and detection using adhered probes
EP1382386A3 (en) 1992-02-19 2004-12-01 The Public Health Research Institute Of The City Of New York, Inc. Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
US5308771A (en) 1992-04-13 1994-05-03 Geo-Centers, Inc. Chemical sensors
EP0565999A2 (en) 1992-04-16 1993-10-20 Siemens Aktiengesellschaft Optical coupling device for two groups of waveguides
US5342737A (en) 1992-04-27 1994-08-30 The United States Of America As Represented By The Secretary Of The Navy High aspect ratio metal microstructures and method for preparing the same
US5296375A (en) 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
CA2135073C (en) 1992-05-06 2002-11-19 Daniel L. Kacian Nucleic acid sequence amplification method, composition and kit
US5266271A (en) 1992-05-22 1993-11-30 Puritan-Bennett Corporation Microsensor copolymer and method of manufacture
GB9212302D0 (en) 1992-06-10 1992-07-22 Applied Research Systems Method for improving measurement precision in evanescent wave optical biosensor assays
CA2115342C (en) 1992-06-17 2003-08-26 Robert B. Wallace A method of detecting and discriminating between nucleic acid sequences
DE69313611T2 (en) 1992-07-02 1998-01-08 Erkki Soini BIOS-SPECIFIC MULTIPARAMETER ANALYSIS PROCEDURE
US5403708A (en) 1992-07-06 1995-04-04 Brennan; Thomas M. Methods and compositions for determining the sequence of nucleic acids
WO1994002515A1 (en) 1992-07-21 1994-02-03 Bunsen Rush Laboratories Inc. Oligomer library formats and methods relating thereto
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
JP3420765B2 (en) 1992-09-14 2003-06-30 エス・アール・アイ・インターナシヨナル Upconvertable reporter for biological and other analysis using laser excitation technology
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5795714A (en) 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
DE4240266A1 (en) 1992-12-01 1994-06-09 Bosch Gmbh Robert Process for the production of optical polymer components with integrated vertical coupling structures
US5541311A (en) 1992-12-07 1996-07-30 Third Wave Technologies, Inc. Nucleic acid encoding synthesis-deficient thermostable DNA polymerase
US5359681A (en) 1993-01-11 1994-10-25 University Of Washington Fiber optic sensor and methods and apparatus relating thereto
US5298741A (en) 1993-01-13 1994-03-29 Trustees Of Tufts College Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample
GB9301122D0 (en) 1993-01-21 1993-03-10 Scient Generics Ltd Method of analysis/separation
JPH08506664A (en) 1993-02-01 1996-07-16 セック，リミテッド Method and apparatus for DNA sequencing
US5556764A (en) 1993-02-17 1996-09-17 Biometric Imaging, Inc. Method and apparatus for cell counting and cell classification
US5313545A (en) 1993-02-19 1994-05-17 Motorola, Inc. Molded waveguide with a unitary cladding region and method of making
AU6357394A (en) 1993-03-04 1994-09-26 Sapidyne, Inc. Assay flow apparatus and method
CA2102884A1 (en) 1993-03-04 1994-09-05 James J. Wynne Dental procedures and apparatus using ultraviolet radiation
FR2703052B1 (en) 1993-03-26 1995-06-02 Pasteur Institut New method of nucleic acid sequencing.
US6048616A (en) * 1993-04-21 2000-04-11 Philips Electronics N.A. Corp. Encapsulated quantum sized doped semiconductor particles and method of manufacturing same
US5512492A (en) 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5677196A (en) 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
JP3157952B2 (en) 1993-06-02 2001-04-23 アヴェンティス・リサーチ・ウント・テクノロジーズ・ゲーエムベーハー・ウント・コー・カーゲー Optical sensor for chemical substance detection
JP3302458B2 (en) 1993-08-31 2002-07-15 富士通株式会社 Integrated optical device and manufacturing method
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
US5415839A (en) 1993-10-21 1995-05-16 Abbott Laboratories Apparatus and method for amplifying and detecting target nucleic acids
US5462700A (en) 1993-11-08 1995-10-31 Alliedsignal Inc. Process for making an array of tapered photopolymerized waveguides
AU8102694A (en) 1993-11-17 1995-06-06 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
US5610287A (en) 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
US5494798A (en) 1993-12-09 1996-02-27 Gerdt; David W. Fiber optic evanscent wave sensor for immunoassay
JPH09506611A (en) 1993-12-15 1997-06-30 コンビケム，インコーポレイテッド Combinatorial library and its use
US5496997A (en) 1994-01-03 1996-03-05 Pope; Edward J. A. Sensor incorporating an optical fiber and a solid porous inorganic microsphere
EP0754240B1 (en) 1994-02-07 2003-08-20 Beckman Coulter, Inc. Ligase/polymerase-mediated genetic bit analysis of single nucleotide polymorphisms and its use in genetic analysis
US5637684A (en) 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
US6100973A (en) * 1994-03-18 2000-08-08 Spectra Science Corporation Methods and apparatus for performing microanalytical techniques using photolithographically fabricated substrates having narrow band optical emission capability
WO1995027078A1 (en) 1994-04-04 1995-10-12 Ciba Corning Diagnostics Corp. Hibridization-ligation assays for the detection of specific nucleic acid sequences
US5552278A (en) 1994-04-04 1996-09-03 Spectragen, Inc. DNA sequencing by stepwise ligation and cleavage
US5714330A (en) * 1994-04-04 1998-02-03 Lynx Therapeutics, Inc. DNA sequencing by stepwise ligation and cleavage
GB2318666B (en) 1994-04-25 1998-07-15 Univ Hertfordshire Coded items for labelling objects
US5856083A (en) * 1994-05-06 1999-01-05 Pharmacopeia, Inc. Lawn assay for compounds that affect enzyme activity or bind to target molecules
US5688997A (en) 1994-05-06 1997-11-18 Pharmacopeia, Inc. Process for preparing intermediates for a combinatorial dihydrobenzopyran library
AU2604795A (en) 1994-05-26 1995-12-21 New York Medical College Detection of halogenated precursors incorporated into dna
CA2191426A1 (en) 1994-05-28 1995-12-07 Stephen John Minter Producing copies of nucleic acids
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5942391A (en) 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
US5876924A (en) * 1994-06-22 1999-03-02 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
US5679773A (en) 1995-01-17 1997-10-21 Affymax Technologies N.V Reagants and methods for immobilized polymer synthesis and display
AU2990595A (en) 1994-07-26 1996-02-22 Sydney Brenner Multidimensional conduit combinatorial library synthesis device
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
DE4428851C2 (en) * 1994-08-04 2000-05-04 Diagnostikforschung Inst Nanoparticles containing iron, their production and application in diagnostics and therapy
US5512490A (en) 1994-08-11 1996-04-30 Trustees Of Tufts College Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns
US5599668A (en) 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
DE69519384T2 (en) * 1994-09-29 2001-05-23 British Telecomm Optical fiber with quantum dots
US6280935B1 (en) * 1994-10-13 2001-08-28 Lynx Therapeutics, Inc. Method of detecting the presence or absence of a plurality of target sequences using oligonucleotide tags
US5846719A (en) * 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5695934A (en) * 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5985356A (en) 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
EP0787288B1 (en) 1994-10-20 2009-03-04 Packard Instrument Company, Inc. Improved imaging method and apparatus
US5795716A (en) * 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5632876A (en) 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
WO1996015271A1 (en) 1994-11-16 1996-05-23 Abbott Laboratories Multiplex ligations-dependent amplification
US5985353A (en) 1994-12-01 1999-11-16 University Of Massachusetts Lowell Biomolecular synthesis of quantum dot composites
US5589351A (en) 1994-12-06 1996-12-31 Nps Pharmaceuticals, Inc. Fluorescence detection apparatus
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
AU5110096A (en) 1995-03-28 1996-10-16 Novartis Ag Process for the production of combinatorial compound libraries
AUPN231395A0 (en) 1995-04-12 1995-05-04 Eastman Kodak Company Electrostatic drop separation in lift printing
US5609826A (en) * 1995-04-17 1997-03-11 Ontogen Corporation Methods and apparatus for the generation of chemical libraries
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
US6340588B1 (en) 1995-04-25 2002-01-22 Discovery Partners International, Inc. Matrices with memories
CN1181720A (en) 1995-04-25 1998-05-13 伊萝莉公司 Remotely programmable matrices with memories and uses thereof
US5858051A (en) 1995-05-08 1999-01-12 Toshiba Machine Co., Ltd. Method of manufacturing optical waveguide
JPH11505126A (en) * 1995-05-19 1999-05-18 アボツト・ラボラトリーズ Wide dynamic range nucleic acid detection using primer series populations
US5747180A (en) * 1995-05-19 1998-05-05 University Of Notre Dame Du Lac Electrochemical synthesis of quasi-periodic quantum dot and nanostructure arrays
US5690894A (en) 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5877280A (en) 1995-06-06 1999-03-02 The Mount Sinai School Of Medicine Of The City University Of New York Thermostable muts proteins
KR19990022596A (en) 1995-06-07 1999-03-25 다니엘 엘. 캐시앙, 헨리 엘. 노르호프 Synthesis of Enzymatically Cleavable Templates and Primer-Based Oligonucleotides
DE69637285T2 (en) 1995-06-07 2008-07-10 Solexa, Inc., Hayward Oligonucleotide tags for sorting and identification
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US6200737B1 (en) * 1995-08-24 2001-03-13 Trustees Of Tufts College Photodeposition method for fabricating a three-dimensional, patterned polymer microstructure
US5656241A (en) 1995-09-07 1997-08-12 Optical Sensors Incorporated Method for manufacturing fiber optic sensors
US5843655A (en) 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
US5665222A (en) 1995-10-11 1997-09-09 E. Heller & Company Soybean peroxidase electrochemical sensor
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
DE69638321D1 (en) * 1995-10-11 2011-03-03 Luminex Corp SIMULTANEOUS MULTI-ANALYSIS OF CLINICAL SAMPLES
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
US5866331A (en) * 1995-10-20 1999-02-02 University Of Massachusetts Single molecule detection by in situ hybridization
GB9521943D0 (en) 1995-10-26 1996-01-03 Univ Hertfordshire Coded particles for process sequence tracking in combinatorial compound library preparation
CA2236788A1 (en) * 1995-11-09 1997-05-15 David Sarnoff Research Center, Inc. Field-assisted sealing
US5772905A (en) 1995-11-15 1998-06-30 Regents Of The University Of Minnesota Nanoimprint lithography
US5780231A (en) 1995-11-17 1998-07-14 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
US5763175A (en) 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
FR2741357B1 (en) 1995-11-22 1998-01-16 Corning Inc METHOD FOR MANUFACTURING A SUPPORT PLATE FOR A TWO-DIMENSIONAL NETWORK OF MICROWELLS, IN PARTICULAR FOR BIOLOGICAL TESTING OR CULTURE
US5633972A (en) 1995-11-29 1997-05-27 Trustees Of Tufts College Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy
US6045760A (en) * 1995-12-05 2000-04-04 Hitachi Koki Co., Ltd. Micro-plate adapter
US5814524A (en) 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
US6090549A (en) * 1996-01-16 2000-07-18 University Of Chicago Use of continuous/contiguous stacking hybridization as a diagnostic tool
US5631337A (en) 1996-01-19 1997-05-20 Soane Bioscience Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis
US5837196A (en) 1996-01-26 1998-11-17 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5766963A (en) 1996-01-26 1998-06-16 Pharmacopeia, Inc. Combination hydroxypropylamine library
EP1958955B1 (en) 1996-02-09 2013-09-04 Cornell Research Foundation, Inc. Spatially addressable oligonucleotide arrays and method of making the same
US5649576A (en) 1996-02-26 1997-07-22 Pharmacopeia, Inc. Partitioning device
US6355198B1 (en) 1996-03-15 2002-03-12 President And Fellows Of Harvard College Method of forming articles including waveguides via capillary micromolding and microtransfer molding
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
US5840256A (en) 1996-04-09 1998-11-24 David Sarnoff Research Center Inc. Plate for reaction system
US5671303A (en) 1996-04-17 1997-09-23 Motorola, Inc. Molecular detection apparatus and method using optical waveguide detection
ES2288760T3 (en) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. ELECTROCINETIC ASSEMBLY CONTROLLED BY LIGHT OF PARTICLES NEXT TO SURFACES.
EP0912761A4 (en) 1996-05-29 2004-06-09 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
EP0923650B1 (en) 1996-06-06 2007-03-07 Solexa, Inc Sequencing by ligation of encoded adaptors
GB2315131B (en) 1996-07-10 2000-11-29 Cambridge Imaging Ltd Improvements in and relating to imaging
GB2315130B (en) 1996-07-10 2001-05-09 Cambridge Imaging Ltd Improved imaging system for fluorescence assays
JP2002515044A (en) 1996-08-21 2002-05-21 スミスクライン・ビーチャム・コーポレイション A rapid method for sequencing and synthesizing bead-based combinatorial libraries
US5775942A (en) * 1996-09-11 1998-07-07 Thomas & Betts Corporation Clamp jaw, lever bypass meter socket
JP3456685B2 (en) 1996-09-13 2003-10-14 日本電信電話株式会社 Fabrication method of waveguide type optical element
US5854684A (en) 1996-09-26 1998-12-29 Sarnoff Corporation Massively parallel detection
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
AU746737B2 (en) * 1996-11-06 2002-05-02 Sequenom, Inc. Compositions and methods for immobilizing nucleic acids to solid supports
US5900481A (en) * 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US5854078A (en) 1996-11-06 1998-12-29 University Of Pittsburgh Polymerized crystalline colloidal array sensor methods
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
DE19647038B4 (en) * 1996-11-14 2007-02-22 Ferro Gmbh Spherical pigments, process for their preparation and their use
US5804384A (en) 1996-12-06 1998-09-08 Vysis, Inc. Devices and methods for detecting multiple analytes in samples
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
DE19653136A1 (en) 1996-12-19 1998-06-25 Wacker Chemie Gmbh Method for stabilizing the gas flow in water-bearing gas deposits and natural gas storage
US5976797A (en) 1996-12-20 1999-11-02 Hitachi Chemical Co., Ltd. Method for quantifying total mRNA with poly(A)-complementary oligonucleotide-immobilized microtiter plate
CA2276462C (en) 1996-12-31 2007-06-12 Genometrix Incorporated Multiplexed molecular analysis system apparatus and method
US5849215A (en) 1997-01-08 1998-12-15 The Regents Of The University Of California Highly ordered nanocomposites via a monomer self-assembly in situ condensation approach
US20020042048A1 (en) 1997-01-16 2002-04-11 Radoje Drmanac Methods and compositions for detection or quantification of nucleic acid species
US20030027126A1 (en) * 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
JPH10268185A (en) 1997-03-27 1998-10-09 Canon Inc Optical apparatus
US6045515A (en) * 1997-04-07 2000-04-04 Lawton; Teri A. Methods and apparatus for diagnosing and remediating reading disorders
JP3666604B2 (en) 1997-04-16 2005-06-29 アプレラ コーポレーション Nucleic acid archiving
KR20010012175A (en) 1997-05-02 2001-02-15 다니엘 엘. 캐시앙, 헨리 엘. 노르호프, 피터 알. 쉬어리 Two-step hybridization and capture of a polynucleotide
US5888885A (en) * 1997-05-14 1999-03-30 Lucent Technologies Inc. Method for fabricating three-dimensional quantum dot arrays and resulting products
US6060743A (en) * 1997-05-21 2000-05-09 Kabushiki Kaisha Toshiba Semiconductor memory device having multilayer group IV nanocrystal quantum dot floating gate and method of manufacturing the same
EP1003904B1 (en) 1997-05-23 2007-07-11 BioArray Solutions Ltd. Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
EP0985142A4 (en) 1997-05-23 2006-09-13 Lynx Therapeutics Inc System and apparaus for sequential processing of analytes
US6008892A (en) 1997-05-23 1999-12-28 Molecular Dynamics, Inc. Optical substrate for enhanced detectability of fluorescence
DE69825939T2 (en) * 1997-05-30 2005-09-15 Matsushita Electric Industrial Co., Ltd., Kadoma Arrangement with quantum boxes
US6096496A (en) * 1997-06-19 2000-08-01 Frankel; Robert D. Supports incorporating vertical cavity emitting lasers and tracking apparatus for use in combinatorial synthesis
EP0993605B1 (en) 1997-06-30 2008-05-21 California Institute Of Technology Compositionally different polymer-based sensor elements and methods for preparing same
US6037186A (en) * 1997-07-16 2000-03-14 Stimpson; Don Parallel production of high density arrays
US6071748A (en) * 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
EP1003910A1 (en) 1997-07-22 2000-05-31 Rapigene, Inc. Multiple functionalities within an array element and uses thereof
AU9020698A (en) 1997-08-15 1999-03-08 Alexion Pharmaceuticals, Inc. Apparatus for performing assays at reaction sites
US6248539B1 (en) 1997-09-05 2001-06-19 The Scripps Research Institute Porous semiconductor-based optical interferometric sensor
NL1007000C2 (en) 1997-09-11 1999-03-12 Dsm Nv Method for the production of articles with a pleasant touch sensation.
JP3727449B2 (en) * 1997-09-30 2005-12-14 シャープ株式会社 Method for producing semiconductor nanocrystal
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US6090553A (en) * 1997-10-29 2000-07-18 Beckman Coulter, Inc. Use of uracil-DNA glycosylase in genetic analysis
US5922617A (en) * 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6207392B1 (en) * 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
WO1999028505A1 (en) 1997-12-03 1999-06-10 Curagen Corporation Methods and devices for measuring differential gene expression
WO1999064867A1 (en) 1997-12-04 1999-12-16 Amersham Pharmacia Biotech Uk Limited Multiple assay method
US6039894A (en) * 1997-12-05 2000-03-21 Sri International Production of substantially monodisperse phosphor particles
US6087114A (en) * 1997-12-09 2000-07-11 Massachusetts Institute Of Technology Optoelectronic sensor
US6270956B1 (en) 1997-12-11 2001-08-07 The Salk Institute For Biological Studies Transcriptional coactivator that interacts with Tat protein and regulates its binding to TAR RNA, methods for modulating Tat transactivation, and uses therefor
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US6063339A (en) 1998-01-09 2000-05-16 Cartesian Technologies, Inc. Method and apparatus for high-speed dot array dispensing
US6280954B1 (en) 1998-02-02 2001-08-28 Amersham Pharmacia Biotech Ab Arrayed primer extension technique for nucleic acid analysis
WO1999039890A1 (en) 1998-02-05 1999-08-12 Nippon Sheet Glass Co., Ltd. Article with rough surface, process for producing the same, and composition therefor
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
DE19815864A1 (en) 1998-04-08 1999-10-14 Europ Lab Molekularbiolog 5'-modified nucleotides and their application in molecular biology and medicine
AU4194899A (en) 1998-05-21 1999-12-06 Hyseq, Inc. Linear arrays of immobilized compounds and methods of using same
EP1090293B2 (en) 1998-06-24 2019-01-23 Illumina, Inc. Decoding of array sensors with microspheres
WO1999067414A1 (en) 1998-06-24 1999-12-29 Glaxo Group Limited Nucleotide detection method
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US5998175A (en) * 1998-07-24 1999-12-07 Lumigen, Inc. Methods of synthesizing and amplifying polynucleotides by ligation of multiple oligomers
US6306643B1 (en) 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
AU6131299A (en) 1998-08-26 2000-03-21 Trustees Of Tufts College Combinatorial polymer synthesis of sensors for polymer-based sensor arrays
US6139626A (en) 1998-09-04 2000-10-31 Nec Research Institute, Inc. Three-dimensionally patterned materials and methods for manufacturing same using nanocrystals
WO2000026411A1 (en) 1998-11-02 2000-05-11 Lynx Therapeutics, Inc. Method for making complementary oligonucleotide tag sets
US6268147B1 (en) * 1998-11-02 2001-07-31 Kenneth Loren Beattie Nucleic acid analysis using sequence-targeted tandem hybridization
US6114038A (en) * 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
US6285807B1 (en) 1998-11-16 2001-09-04 Trustees Of Tufts College Fiber optic sensor for long-term analyte measurements in fluids
EP1003078A3 (en) 1998-11-17 2001-11-07 Corning Incorporated Replicating a nanoscale pattern
DE19856796A1 (en) 1998-12-09 2000-06-15 Biochip Technologies Gmbh Cleavage of chemically synthesized oligo- / polynucleotides at a predetermined location
US6129896A (en) 1998-12-17 2000-10-10 Drawn Optical Components, Inc. Biosensor chip and manufacturing method
US6429027B1 (en) * 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
AU771458B2 (en) 1999-02-09 2004-03-25 Illumina, Inc. Automated information processing in randomly ordered arrays
US20020150909A1 (en) 1999-02-09 2002-10-17 Stuelpnagel John R. Automated information processing in randomly ordered arrays
ATE462970T1 (en) 1999-02-09 2010-04-15 Illumina Inc SCREENING METHOD USING POROUS MICROBEADS AND COMPOSITIONS
GB9902970D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Novel matrix
EP1165839A2 (en) 1999-03-26 2002-01-02 Whitehead Institute For Biomedical Research Universal arrays
AU778438B2 (en) * 1999-04-06 2004-12-02 Yale University Fixed address analysis of sequence tags
US6284465B1 (en) 1999-04-15 2001-09-04 Agilent Technologies, Inc. Apparatus, systems and method for locating nucleic acids bound to surfaces
US6355431B1 (en) * 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
EP1923472B1 (en) 1999-04-20 2012-04-11 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
AU4701200A (en) * 1999-05-07 2000-11-21 Quantum Dot Corporation A method of detecting an analyte using semiconductor nanocrystals
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
EP1190100B1 (en) 1999-05-20 2012-07-25 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
ATE338273T1 (en) 1999-05-20 2006-09-15 Illumina Inc DEVICE FOR HOLDING AND PRESENTING AT LEAST ONE MICRO SPHERE MATRIX FOR SOLUTIONS AND/OR OPTICAL IMAGING SYSTEMS
US20020051971A1 (en) 1999-05-21 2002-05-02 John R. Stuelpnagel Use of microfluidic systems in the detection of target analytes using microsphere arrays
DK1218545T3 (en) 1999-08-18 2012-02-20 Illumina Inc Methods of Preparation of Oligonucleotide Solutions
AU2246601A (en) 1999-08-30 2001-04-10 Illumina, Inc. Methods for improving signal detection from an array
CA2384838C (en) 1999-09-13 2006-07-18 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
US6517995B1 (en) 1999-09-14 2003-02-11 Massachusetts Institute Of Technology Fabrication of finely featured devices by liquid embossing
US6500603B1 (en) 1999-11-11 2002-12-31 Mitsui Chemicals, Inc. Method for manufacturing polymer optical waveguide
JP4507315B2 (en) 1999-11-24 2010-07-21 凸版印刷株式会社 Manufacturing method of optical / electrical wiring board
ATE527053T1 (en) 1999-12-13 2011-10-15 Illumina Inc SYNTHESIS DEVICE FOR OLIGONUCLEOTIDES USING CENTRIFLY FORCE
EP1240498B1 (en) 1999-12-23 2008-12-17 Illumina, Inc. Decoding of array sensors with microspheres
JP2001185752A (en) 1999-12-24 2001-07-06 Nippon Telegr & Teleph Corp <Ntt> Semiconductor device and optical signal input/output device using the same
EP1990428B1 (en) * 2000-02-07 2010-12-22 Illumina, Inc. Nucleic acid detection methods using universal priming
EP1255865B1 (en) 2000-02-07 2007-04-18 Illumina, Inc. Nucleic acid detection method using universal priming
AU2001239760B2 (en) 2000-02-10 2005-11-24 Illumina, Inc. Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
EP1257668B1 (en) * 2000-02-16 2008-10-29 Illumina, Inc. Parallel genotyping of multiple patient samples
JP2001318257A (en) 2000-05-11 2001-11-16 Mitsui Chemicals Inc Method for producing polymeric optical waveguide
AU7166201A (en) 2000-06-28 2002-01-08 Illumina Inc Composite arrays utilizing microspheres with a hybridization chamber
AU2001279056A1 (en) 2000-07-28 2002-02-13 Goodrich Corporation Optical waveguides and methods for making the same
WO2002012897A2 (en) 2000-08-09 2002-02-14 Illumina, Inc. Automated information processing in randomly ordered arrays
AU2001288393A1 (en) 2000-08-25 2002-03-04 Illumina, Inc. Probes and decoder oligonucleotides
JP2002071993A (en) 2000-09-05 2002-03-12 Matsushita Electric Ind Co Ltd Optical waveguide substrate, method of manufacturing the same, optical waveguide parts and method of manufcturing the same
AU2001288751A1 (en) 2000-09-05 2002-03-22 Illumina, Inc. Cellular arrays comprising encoded cells
JP2004523906A (en) 2000-10-12 2004-08-05 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Templates for room-temperature and low-pressure micro and nano-transfer lithography
AU2002239780A1 (en) * 2000-10-25 2002-06-03 Tufts University Polymeric microspheres
DE10054373B4 (en) 2000-10-30 2004-08-12 Infineon Technologies Ag Method and device for producing large-area planar waveguide structures
AU2002326290A1 (en) 2001-03-01 2002-12-16 Illumina, Inc. Methods for improving signal detection from an array
JP4604385B2 (en) 2001-04-18 2011-01-05 凸版印刷株式会社 Manufacturing method of optical waveguide
CA2450139A1 (en) 2001-06-11 2002-12-19 Illumina, Inc Multiplexed detection methods
US6813077B2 (en) 2001-06-19 2004-11-02 Corning Incorporated Method for fabricating an integrated optical isolator and a novel wire grid structure
WO2003002979A2 (en) 2001-06-28 2003-01-09 Illumina, Inc. Multiplex decoding of array sensors with microspheres
EP1481076A4 (en) 2001-07-12 2005-05-11 Illumina Inc Multiplex nucleic acid reactions
US6748975B2 (en) 2001-12-26 2004-06-15 Micralyne Inc. Microfluidic valve and method of manufacturing same
US6653030B2 (en) 2002-01-23 2003-11-25 Hewlett-Packard Development Company, L.P. Optical-mechanical feature fabrication during manufacture of semiconductors and other micro-devices and nano-devices that include micron and sub-micron features
US20030217804A1 (en) 2002-05-24 2003-11-27 Guo Lingjie J. Polymer micro-ring resonator device and fabrication method
CN1304861C (en) 2002-06-27 2007-03-14 松下电器产业株式会社 Optical waveguide and method for mfg. same
JP2004069743A (en) 2002-08-01 2004-03-04 Fuji Xerox Co Ltd Manufacture method for macromolecular optical waveguide
US6887792B2 (en) 2002-09-17 2005-05-03 Hewlett-Packard Development Company, L.P. Embossed mask lithography
JP2004144987A (en) 2002-10-24 2004-05-20 Fuji Xerox Co Ltd Manufacturing method of polymeric optical waveguide
KR100943561B1 (en) 2003-06-03 2010-02-22 엘지전자 주식회사 A method of making a wavelength filter
JP4175183B2 (en) 2003-06-04 2008-11-05 富士ゼロックス株式会社 Method for producing polymer optical waveguide
US9809163B2 (en) 2015-04-14 2017-11-07 Harman International Industries, Incorporation Techniques for transmitting an alert towards a target area
US9805025B2 (en) 2015-07-13 2017-10-31 Seal Software Limited Standard exact clause detection

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998040726A1 (en) * 1997-03-14 1998-09-17 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
WO1998050782A2 (en) * 1997-05-05 1998-11-12 Trustees Of Tufts College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
WO1999018434A1 (en) * 1997-10-06 1999-04-15 Trustees Of Tufts College Self-encoding fiber optic sensor

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US8691594B2 (en) 1996-04-25 2014-04-08 Bioarray Solutions, Ltd. Method of making a microbead array with attached biomolecules
US9400259B2 (en) 1996-04-25 2016-07-26 Bioarray Solutions, Ltd. Method of making a microbead array with attached biomolecules
US9377388B2 (en) 1997-03-14 2016-06-28 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US9273354B2 (en) 1997-05-23 2016-03-01 Illumina, Inc. System and apparatus for sequential processing of analytes
US9157113B2 (en) 1997-10-06 2015-10-13 Trustees Of Tufts College, Tufts University Self-encoding sensor with microspheres
US8426217B2 (en) 1997-10-06 2013-04-23 Trustees Of Tufts College Self-encoding sensor with microspheres
US8030094B2 (en) 1997-10-06 2011-10-04 Trustees Of Tufts College Self-encoding sensor with microspheres
US8691591B2 (en) 1997-10-06 2014-04-08 Trustees Of Tufts College Self-encoding sensor with microspheres
US7754498B2 (en) 1997-10-06 2010-07-13 Trustees Of Tufts College Self-encoding sensor with microspheres
US9399795B2 (en) 1998-06-24 2016-07-26 Illumina, Inc. Multiplex decoding of array sensors with microspheres
US9279148B2 (en) 1999-04-20 2016-03-08 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US9441267B2 (en) 1999-04-20 2016-09-13 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US9289766B2 (en) 1999-05-21 2016-03-22 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8883424B2 (en) 1999-05-21 2014-11-11 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US9416411B2 (en) 1999-08-18 2016-08-16 Illumina, Inc. Compositions and methods for preparing oligonucleotide solutions
US8906626B2 (en) 2000-02-07 2014-12-09 Illumina, Inc. Multiplex nucleic acid reactions
US9436088B2 (en) 2001-06-21 2016-09-06 Bioarray Solutions, Ltd. Un-supported polymeric film with embedded microbeads
US9251583B2 (en) 2002-11-15 2016-02-02 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US8691754B2 (en) 2003-09-22 2014-04-08 Bioarray Solutions, Ltd. Microparticles with enhanced covalent binding capacity and their uses
US9147037B2 (en) 2004-08-02 2015-09-29 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification

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